Read full Article Publication I December 7, 2018 Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus Celastrol is a natural pentacyclic triterpene used in traditional Chinese...
DOWNLOAD BROCHURE Brochure I December 14, 2018 Biophysical characterization of bispecific antibodies developed for enhancement of dual-targeting specificity with switchSENSE® The measurement of kinetic rates and avidity binding in the simultaneous engagement of two...
Read App Note App Note I November 21, 2018 Measuring ligation activity of T4 DNA ligase on nicked DNA with switchSENSE® DNA ligases fulfill essential functions in DNA replication, DNA repair, and are standard tools in molecular biology labs. Here, we describe a...
Read App Note App Note I November 12, 2018 Sizing Analysis of the Ubiquitin / E1-E2-E3 Complex using switchSENSE® technology During the posttranslational process of ubiquitination, the small regulatory protein ubiquitin (Ub) is covalently attached to a lysine residue...
Read full Article Publication I November 8, 2018 Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues A combined structural and quantitative biophysical profile of the DNA binding affinity, kinetics and...