Read full Article Publication I June 7, 2024 Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended...
View Webinar Webinar I May 14, 2024 DISCOVER screening of PROTACs/molecular glues: ternary complex analysis with induced proximity This is the fourth episode of our second season of the DISCOVER MOLECULAR INTERACTIONS webinar series. Each month we will talk about...
Read full Article Publication I May 2, 2024 Balancing the Affinity and Tumor Cell Binding of a Two-in-One Antibody Simultaneously Targeting EGFR and PD-L1 The optimization of the affinity of monoclonal antibodies is crucial for the development of drug candidates, as...
View Webinar Webinar I April 17, 2024 DISCOVER therapeutic antibodies: kinetics of antibody-drug conjugates measured directly on cells This is the third episode of our second season of the DISCOVER MOLECULAR INTERACTIONS webinar series. Each month we will talk about...
Read full Article Publication I January 18, 2024 DNA origami traps for large viruses Virus-enveloping macromolecular shells or tilings can prevent viruses from entering cells. Here, we describe the design and assembly of a cone-shaped DNA origami higher-order assembly...