View Webinar Webinar I April 17, 2024 DISCOVER small molecule-induced protein conformational changes using DNA origami nanolevers This is the sixth episode of our second season of the DISCOVER MOLECULAR INTERACTIONS webinar series. Each month we will talk about...
Read full Article Publication I June 7, 2024 Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended...
Read full Article Publication I September 13, 2021 Tailored Biosensors for Drug Screening, Efficacy Assessment, and Toxicity Evaluation Biosensors have been flourishing in the field of drug discovery with pronounced developments in the past few years. They facilitate...
Read full Article Publication I December 7, 2023 Kinetic FRET Assay to Measure Binding-Induced Conformational Changes of Nucleic Acids The interaction of small molecules or proteins with RNA or DNA often involves changes in the nucleic acid (NA) folding and structure....
Read full Article Publication I November 27, 2023 Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction The classical Non-Homologous End Joining (c-NHEJ) pathway is the predominant process in mammals...