Can I combine different buffers in one assay?

Yes, the heliX+ instrument has three different buffer lines. One is used for the maintenance buffer, facilitating standard protocols like functionalization. The other two can be equipped with your individual measurement buffers. The heliOS software has a smart priming...

How much sample do I need for my experiment?

We know your samples are precious. So we optimized the switchSENSE® technology for minimum sample consumption. You will need approximately 5 pmol ligand per experimental run. Of course, this highly depends on your exact experimental conditions. You can always contact...

Can I perform high-throughput screenings with switchSENSE®?

The heliX+ instruments were designed to fit your specific needs. You can easily scale up your throughput by combining as many heliX+ modules as you require. This modular design offers high versatility – you can combine heliX units in one heliOS network, operate them...

Can I multiplex with switchSENSE®?

Yes, with a heliX+ you can multiplex up to four interactions due to four single-photon detectors. Two colors can be detected on each of the two sensor spots. And if you want to scale up your throughput, you can combine several heliX+ instruments in one...

Can I examine multispecific binders with switchSENSE®?

Yes! You can either functionalize the surface with two different ligands and differentiate between affinity and avidity. Or you can use the specific DNA Y-structure to examine bispecific analytes, ternary complex formation or protein dimerization.